PP17

The 2017 Purine and Pyrimidine Society meeting PP17 will be held in Gdańsk, Poland from 20-24 September 2017

Venue:
Gdansk Marina Novotel,
Jelitkowska 20, 80-342 Gdansk,
tel: +48 58 558 91 00

To make reservation for PP17 please ring +48 58 558 91 11 or +48 58 558 91 12, or email: h3375-re@accor.com or h3375-re1@accor.com

Please click for Novotel Marina website, its facilities and directions (not for reservations)


Symposium Infomation:


Click here to download Purine_and_Pyrimidine_Society_PP17_Gdansk_Program_and_Abstract_Book

Please use hotel website above for information how to get there

Please be careful with taxi service as some services are dishonest. It is much better to order taxi by phone. We recommend AS taxi

www.astaxi.pl

Tel: +48 58 19 660, +48 58 302 23 03, +48 660 619 660

Cost of transfer from airport to Novotel Marina: 35 PLN (during day 6-22) or 50 PLN (during night 22-6). AS Taxi can accept card payments

Please be careful with money exchange. Never trust people on the street and use Kantor/Money exchange. Money exchange offices outside airport offer better rates. Current exchange rate: 1 EUR = 4.3 PLN, 1 USD = 3.6





PP17 PROGRAMME

Programme include special lectures (35 min + 5 min discussion), invited lectures (25 min with 5 min discussion), oral communications (15 min with 5 min discussion), short oral communication (5 min + 5 min discussion) and poster only presentations.

All presenters of oral communications as an option can also display poster. Poster boards (120 cm high 100 cm wide) will be available for all.

Please email me at rt.smolenski@gmail.com with comments and requests for changes

PP17 PROGRAMME

20.09.2017

16.00 - Registration starts

18.00 – 21.00 Welcome reception at Novotel Marina Gdansk

21.09.2017

09.00 - 9.50 Symposium start/ANNE SIMMONDS MEMORIAL LECTURE by David Perrett

SESSION 1 - Purine and Pyrimidine Metabolism and Enzymology, Chair: David Perrett, Andrzej Skladanowski

9.50 - 10.20 PYRIMIDINES IN THE CENTRAL NERVOUS SYSTEM: PERSPECTIVES ON PAST AND PRESENT M. Löffler, E. A. Carrey, E. Zameitat, M.K.H. Schäfer

10.20 - 10.40 INSIGHTS INTO THE ROLE OF DCTPP1 IN PYRIMIDINE NUCLEOTIDE HOMEOSTASIS Martinez-Arribas B, L.M. Ruiz-Pérez, A.E. Vidal & D. González-Pacanowska

10.40 - 11.00 METABOLIC ALTERATIONS BY NON-PURINE-ANALOG XANTHINE OXIDOREDUCTASE INHIBITORS DURING ISCHEMIA-REPERFUSION PROCESS Ken Okamoto, Takashi Tani

11.00 - 11.30 Coffee break

11.30 - 11.50 AICAR EFFECT IN EARLY NEURONAL DEVELOPMENT Torres RJ, Puig JG

11.50 - 12.00 METABOLISM OF 4-PYRIDONE-3-CARBOXAMIDE RIBONUCLEOSIDE (4PYR) IN ENDOTHELIAL AND CANCER CELLS – INFLUENCE ON CELLULAR ENERGY METABOLISM Pelikant-Malecka I, Smolenski RT, Slominska EM

12.00 - 12.10 PLASMA CONCENTRATION OF 4-PYRIDONE-3-CARBOXAMIDE-1-ß-D-RIBONUCLEOSIDE (4PYR) IN LUNG CANCER P.Jablonska, P. Zukowska, R.T. Smolenski, W. Rzyman, E.M.Slominska

12.10 - 12.20 NICOTINAMIDE AND 4-PYRIDONE-3-CARBOXYAMIDE METABOLISM ALTERATIONS IN CANCER DEVELOPMENT Zukowska P, Gawlik-Jakubczak T, Jablonska P, Zabielska M, Pelikant-Malecka I, Kutryb-Zajac B, Bulinska A, Smolenski RT, Matuszewski M, Slominska EM

12.20 - 12.30 NAD POOL IN THE HEART DURING REPEATED ISCHEMIC EPISODES Zabielska M, Bulinska A, Slominska EM, Smolenski RT

13.00 - 14.30 Lunch

SESSION 2 - Nucleoside Transporters, Chair:Marçal Pastor Anglada, Imogen Coe

14.30 - 15.00 THE DEVELOPMENT OF INNOVATIVE APPROACHES TO IMPROVED NUCLEOSIDE ANALOG DRUG THERAPIES THROUGH ENHANCED UNDERSTANDING OF EQUILIBRATIVE NUCLEOSIDE TRANSPORTERS Imogen Coe

15.00 - 15.30 PHYSIOLOGICAL AND PHARMACOLOGICAL IMPACT OF NUCLEOSIDE TRANSPORTER REGULATION, Marçal Pastor-Anglada

15.30 - 15.50 MIRNA BEHIND HUMAN CONCENTRATIVE NUCLEOSIDE TRANSPORTERS (HCNTS) REGULATION S. Pérez-Torras C. Boces-Pascual, M. Gironella, L. Boix, M. Pastor-Anglada

15.50 - 16.10 ROLE OF DRUG-DEPENDENT TRANSPORTER MODULATION ON THE CHEMOSENSITIVITY OF CHOLANGIOCARCINOMA N. Urtasun, C. Boces-Pascual, L. Boix, J. Bruix, M. Pastor-Anglada, S. Pérez-Torras.

16.10 - 17.30 Coffee break/Poster session

SESSION 3 - Purinergic Signalling and Extracellular Metabolism, Chair: Tadeusz Pawełczyk, Barbara Kutryb-Zając

17.30 - 18.00 PURINES AND THE FUNCTION OF T AND B LYMPHOCYTES IN DIABETES Pawelczyk T

18.00 - 18.30 NUCLEOTIDE CONVERTING ECTO-ENZYMES PATTERN IN VASCULAR INFLAMMATION AND ATHEROSCLEROSIS B. Kutryb-Zajac P. Zukowska, A. Bulinska, A. Jasztal, P. Jablonska, M. Serocki, R. Bartoszewski, R. Lango, J. Rogowski, E.M. Slominska, R.T. Smolenski

18.30 - 18.50 THE ROLE OF ECTO-5'-NUCLEOTIDASE IN AORTIC VALVE AND ENDOTHELIUM DYSFUNCTION Zukowska P, Kutryb-Zajac B, Jasztal A, Toczek M, Zabielska M, Borkowski T, Khalpey Z, Smolenski RT, Slominska EM

19.00 - 20.00 Meeting of PPS Board

22.09.2017

SESSION 4 - Inborn Errors of Purine and Pyrimidine Metabolism, Chair: Lynette Faibanks, André Van Kuilenburg

9.00 - 9.30 THE PIVOTAL ROLE OF DIHYDROPYRIMIDINE DEHYDROGENASE IN INBORN ERRORS OF METABOLISM AND ONCOLOGY A.B.P. van Kuilenburg

9.30 - 9.50 EXPRESSION PROFILING AND BIOINFORMATICS ANALYSIS OF DYSREGULATED MICRORNAS (MIRNAS) IN MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOMYOPATHY (MNGIE) M. Levene, F.J.Enguita and B.E. Bax

9.50 - 10.10 LC-MS/MS DETECTION OF BIOCHEMICALLY PREPARED INTERMEDIATES OF DE NOVO PURINE SYNTHESIS M. Krijt V. Skopova, V. Baresova, O. Souckova, J. Krijt, M. Zikanova

10.10 - 10.30 HPRT DEFICIENCY WITHOUT APPARENT HPRT DEFICIENCY Torres RJ, Puentes S, Menendez A, Fernandez N

10.30 - 10.50 PATHOGENETIC ASPECTS OF HEREDITARY XANTHINURIA I.Sebesta, B. Stiburkova

10.50 - 11.10 Coffee break

11.10 - 11.30 ADAPTATION OF SAMHD1-MUTATED HUMAN FIBROBLASTS TO ABNORMALLY HIGH DNTP POOLS E. Franzolin, S. Coletta; P. Ferraro; M Stevanoni; A Russo; S. Cagnin; V. Bianchi & C. Rampazzo

11.30 - 11.50 ALTERED PRE-MRNA SPLICING CAUSED BY A NOVEL INTRONIC MUTATION C.1443+5G>A IN THE DIHYDROPYRIMIDINASE (DPYS) GENE Yoko Nakajima, Judith Meijer, Chunhua Zhang, Xu Wang, Tetsuya Ito, Doreen Dobritzsch, André B. P. Van Kuilenburg

11.50 - 12.10 STUDY OF THE PURINOSOME IN HELA CELLS AND CAENORHABDITIS ELEGANS MODEL SYSTEMS O. Souckova, V. Skopova, V. Baresova, O. Souckova, J. Krijt, M. Zikanova

12.10 - 12.30 A CAENORHABDITIS ELEGANS MODEL OF ADENYLOSUCCINATE LYASE DEFICIENCY REVEALS NEUROMUSCULAR AND REPRODUCTIVE PHENOTYPES OF DISTINCT ETIOLOGY Wendy Hanna-Rose

12.30 - 12.40 GLUT9 INFLUENCES URIC ACID CONCENTRATION IN PATIENTS WITH LESCH NYHAN DISEASE Torres RJ, Puig JG

12.40 - 13.40 Lunch

SESSION 5 - Purines and Pyrimidines in Mitochondria and Mitochondrial Disorders, Chair: M Hirano, Spinazzola, A

13.40 - 14.10 DEOXYNUCLEOTIDE INSUFFICIENCY AND DNA REPLICATION IN MITOCHONDRIA A Spinazzola

14.10 - 14.40 A SUBSTANTIAL FRACTION OF MITOCHONDRIAL dTTP AND dGTP IS BOUND TO RESPIRATORY CHAIN COMPLEX I Y. Cámara, E. González-Vioque, D. Molina-Granada, R. Cabrera-Pérez, J. Torres-Torronteras, R. Martí.

14.40 - 15.10 DEVELOPMENT OF A PHARMACOLOGICAL THERAPY FOR THYMIDINE KINASE 2 (TK2) DEFICIENCY, Michio Hirano, Carlos Lopez-Garcia, Xiomara Rosales, Kristen Engelstad, Jasim Uddin, Ramon Marti, Caterina Garone.

15.10 - 15.30 DEVELOPMENT OF CEREBRAL ORGANOID CULTURES FOR THE STUDY OF THE NEURONAL PATHOMOLECULAR MECHANISMS OF MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOMYOPATHY (MNGIE) Pacitti D Bax BE.

15.30 – 20.00 Sightseeing trip

23.09.2017

SESSION 6 - Gout and Hyperuricaemia, Chair: Ivan Sebesta, Kimoyoshi Ichida

09.00 - 09.30 GWAS OF CLINICALLY-ASCERTAINED GOUT AND ITS SUBTYPES IDENTIFIED TEN LOCI THAT INCLUDE URATE TRANSPORTER GENES Matsuo, H, Akiyoshi Nakayama, Hirofumi Nakaoka, Ken Yamamoto, Masayuki Sakiyama, Amara Shaukat, Yu Toyoda, Yukinori Okada, Yoichiro Kamatani, Tappei Takada, Seiko Shimizu, Makoto Kawaguchi, Kenji Wakai, Michiak Kuboi,Hiroshi Ooyamaj, Toru Shimizu, Kimiyoshi Ichida, Tony R Merriman on behalf of Eurogout Consortium, Nariyoshi Shinomiya

09.30 - 09.50 ALLELIC VARIANTS OF ABCG2 AND GOUT RISK Blanka Stiburkova Katerina Pavelcova, Jakub Zavada, Lenka Petru, Marketa Pavlikova, Hirotaka Matsuo, Karel Pavelka

09.50 - 10.10 URATE-LOWERING EFFECTS WITH INCREASED RENAL URATE EXCRETION BY NONFUNCTIONAL VARIANTS OF URAT1/SLC22A12 IN JAPANESE POPULATION A. Nakayama H. Matsuo, Y. Kawamura, S. Shimizu, M. Kawaguchi, M. Sakiyama, T. Higashino, M. Komatsu, M. Nakajima, T. Takada, K. Ichida, K. Wakai, & N. Shinomiya.

10.10 - 10.30 ABCG2-MEDIATED DRUG INTERACTION RISKS WITH FEBUXOSTAT MEDICATION T. Takada, H. Miyata, Y. Toyoda, H. Matsuo, K. Ichida & H. Suzuki

10.30 - 11.00 Coffee break

SESSION 7 - Purine and Pyrimidine metabolism in Cardiovascular, Immune and Neurological Disorders and Parasitic Disease, Chair: Maria Valente, Ryszard T. Smolenski

11.00 - 11.20 ROLE OF THYMIDINE KINASE IN PYRIMIDINE NUCLEOTIDE HOMEOSTASIS IN TRYPANOSOMA BRUCEI Maria Valente, Víctor M. Castillo-Acosta, Luis M. Ruiz-Pérez & Dolores González-Pacanowska

11.20 - 11.40 ITPASE EXPRESSION DURING THE HAEMATOPOIESIS IN NORMAL BONE MARROW: A MULITPARAMETER FLOW-CYTOMETRIC APPROACH Lindelau K, Kraaijvanger, J. Bakker, J. Bierau, M. Leers

11.40 - 12.00 ROLE OF URIC ACID AS A SCAVENGER OF REACTIVE OXYGEN SPECIES IN THE NEURONAL CELL T. Kusano, T Nishino & K. Okamoto

12.00 - 12.20 AN ALTERED NUCLEOTIDE METABOLISM AS A NOVEL MECHANISM LEADING TO HUNTINGTON DISEASE RELATED CARDIOMYOPHATY Marta Toczek, Daniel Zielonka, Paulina Zukowska, Jerzy T. Marcinkowski, Barbara Kutryb-Zajac, Ewa Slominska, Mark Isalan, Michal Mielcarek , Ryszard T. Smolenski

12.20 - 12.30 DRUG RESISTANT EPILEPSY - IS IT WORTH TO LOOK FOR PURINE AND PYRIMIDINE DISORDERS? Agnieszka Sawicka, Maria Mazurek-Beldzinska

12.30 - 13.00 MULTIOMICS PLATFORM FOR ANALYSIS OF BIOLOGICAL SAMPLES. Lukasz Nowicki, Perlan Technologies

13.00 - 14.30 Lunch

SESSION 8 - Purines and Pyrimidines in Cancer, Chair: Frits Peters, Varsha Gandhi, Katarzyna Lubecka

14.30 - 15.20 TARGETING NUCLEOTIDE METABOLISM PATHWAYS AS ANTI-CANCER TREATMENT Thomas Helleday

15.20 - 15.50 OXIDATIVE PHOSPHORYLATION (OXPHOS) INHIBITION AS A THERAPEUTIC STRATEGY Varsha Gandhi

15.50 - 16.20 RE-EVALUATION OF BREQUINAR SODIUM, A DIHYDROOROTATE DEHYDROGENASE (DHO-DH) INHIBITOR / ANTIPYRIMIDINE EFFECTS OF FIVE DIFFERENT PYRIMIDINE DE NOVO INHIBITORS GJ Peters

16.20 - 16.40 THE INVOLVEMENT OF 5’-NUCLEOTIDASES cN-II AND CD73 IN BREAST CANCER CELL AGGRESSIVENESS O. Cadassou, E. Cros-Perrial, C. Armanet, M. Balde, K. Chettab, C. Dumontet, L.P. Jordheim

16.40 - 17.00 CN-II SILENCING COUNTERACTS TUMORAL PHENOTYPE IN LUNG CARCINOMA CELL LINE A549 Pesi R Petrotto E., Colombaioni L., Allegrini S., Garcia-Gil M, Camici M, Jordheim LP and Tozzi MG

17.00 - 17.10 DETERMINING PREANALYTICAL CONDITIONS FOR cN-II ACTIVITY ASSESSMENT IN CLINICAL SAMPLES E. Cros-Perriala J.Y. Puy, S. Peyrottes, I. Lefebvre, C. Dumontet, L.P. Jordheim

17.10 - 17.40 Coffee break

17.40 - 18.00 FRAGMENT-BASED DRUG DESIGN OF CYTOSOLIC 5’-NUCLEOTIDASE II INHIBITORS Egron D, Chaloin L. , Jordheim L.P. , Krimm I. , Aghajari N. , Lionne C. , Dumontet C. , Périgaud C. , & Peyrottes S.

18.00 - 18.20 A NOVEL COMBINATION OF CLOFARABINE AND SULFORAPHANE REACTIVATES DNA METHYLATION-SILENCED TUMOUR SUPPRESSOR GENES IN HUMAN BREAST CANCER CELLS Katarzyna Lubecka Agnieszka Kaufman-Szymczyk, Barbara Stefanska, Barbara Cebula-Obrzut, Piotr Smolewski, Krystyna Fabianowska-Majewska

18.20 - 18.40 NUCLEOSIDIC PHOSPHOANTIGENS AS POTENT TOOLS FOR Vg9Vd2 T CELL ACTIVATION J. Alguacil M. Moulin, E. Champagne & S. Peyrottes

18.40 - 19.00 MECHANISM OF DNMT1 DOWNREGULATION BY THE NOVEL EPIGENETIC MODULATOR RX-3117 Sarkisjan, D, Btissame el Hassouni, Young B. Lee, Deog J. Kim, G.J. Peters

20.00 - 23.00 Symposium Dinner/PPS General assembly

24.09.2017 Optional Sightseeing trips

POSTER ONLY PRESENTATIONS

LACTOBACILLUS GASSERI PA-3 UTILIZES THE PURINES GMP AND GUANOSINE AND DECREASES THEIR ABSORPTION IN RATS N. Yamada, C. Saito, Y. Chiba, and H. Kano

LACTOBACILLUS GASSERI PA-3, BUT NOT L. GASSERI OLL2996, REDUCES THE ABSORPTION OF PURINE NUCLEOSIDES IN RATS H. Kano C. Saito, Y. Chiba, and N. Yamada

URIDINE MONOPHOSPHATE SYNTHETASE ENABLES EUKARYOTIC DE NOVO NAD+ BIOSYNTHESIS FROM QUINOLINIC ACID Melanie R. McReynolds, Wenqing Wang, Lauren M. Holleran, and Wendy Hanna-Rose

DNA METHYLTRANSFERASE (DNMT1) AND URIDINE-CYTIDINE KINASE (UCK2) EXPRESSION IN VARIOUS HUMAN TUMORS Sarkisjan, D, Daniel D de Klerk, Kees Smid, Richard J Honeywell, Michael H. Kristensen, Young B. Lee, Deog J. Kim, G.J. Peters

KINETICS OF 5′-[α,β-METHYLENE]DIPHOSPHATEβ-METHYLENE)-ADP (AOPCP) IN MICE BLOOD Marta Toczek Ewa Slominska ,Ryszard T. Smolenski

REARRANGEMENT OF CARDIAC ENERGY METABOLISM IN CD73 DEFICENT MICE Marta Toczek, Mariola Olkowicz, Paulina Zukowska, Ewa Slominska, Ryszard T. Smolenski

INTER-INDIVIDUAL VARIABILITY OF SERUM XANTHINE OXIDASE ACTIVITY IN IBD PATIENTS Meijer, B. M. L. Seinen, T. Hosman, R. K. Linskens, J. C. Kneppelhout, G. J. Peters, C. J. Mulder,A. A. van Bodegraven and N. K. de Boer

ATP CONCENTRATION AND MITOCHONDRIAL FUNCTION IN HEARTS OF ATHEROSCLEROTIC MICE A Bulinska, M Zabielska, I Pelikant-Malecka, EM Slominska, RT Smolenski

ACTIVITIES OF PURINE CONVERTING ENZYMES IN HEART, LIVER AND KIDNEY LDLR-/- AND APO E-/- MICE Rybakowska I.M., Kutryb-Zając B., Milczarek R., Slominska E.M., Smolenski R.T.

ELEVATED SERUM URIC ACID LEVELS IN PATIENTS WITH COELIAC DISEASE Joanna Karbowska, Katarzyna Gladys, Marek Guzek, Krystian Adrych, Ryszard T. Smolenski, Zdzislaw Kochan

THE SIMULTANEOUS OVEREXPRESSION OF CD39/CD73 ECTONUCLEOTIDASES, VIA A MULTICISTRONIC GENETIC ENGINEERING APPROACH, IS ASSOCIATED WITH HIGHER AMOUNT OF ADENOSINE IN DIFFERENT TISSUES OF TRANSGENIC MICE Noemi Di Marzo, Paulina Zukowska, Magdalena Zabielska, Elisa Chisci, Marco De Giorgi, Ewa M Slominska, Ryszard T. Smolenski, Marialuisa Lavitrano, Roberto Giovannoni

NUCLEOTIDE AND ADENOSINE SIGNALING IN CALCIFIC AORTIC VALVE DISEASE B. Kutryb-Zajac P. Jablonska, P. Zukowska, A. Jasztal, D. Friebe, M. Serocki, R. Bartoszewski, R. Lango, J. Rogowski, E.M. Slominska, J. Schrader, M.H. Yacoub, R.T. Smolenski

EFFECTS OF NICOTINAMIDE N-METHYLTRANSFERASE GENE SILENCING ON ENDOTHELIAL BIOENERGETICS Roberto Campagna, Łukasz Mateuszuk, Patrycja Kaczara, Davide Sartini, Monica Emanuelli, Stefan Chlopicki

CHANGE IN THE PURINE COMPOSITION OF FOOD BY SOAKING IN SAKE LEES F.Takayanagi, T. Fukuuchi, N. Yamaoka, K. Kaneko

PROTEOMIC ANALYSIS OF A URINARY STONE WITH TWO LAYERS COMPOSED OF CALCIUM OXALATE MONOHYDRATE AND URIC ACID K. Kaneko M. Kabeya, H. Kondo, N. Chishima, T. Fukuuchi, N. Yamaoka, and M. Yasudab

MEASUREMENT OF PURINE CONTENT IN UMAMI SOUP AND EVALUATION OF ITS EFFECTS ON EXTRA- AND INTRACELLULAR PURINE METABOLISM USING HPLC SIMULTANEOUS DETERMINATION T. Fukuuchi, N. Iyama, N. Yamaoka, K. Kaneko

NAD METABOLITES IN BLOOD OF PATIENTS WITH SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK B. Drogoszewska, P. Chomik, A. Poleniewicz, L. Garbacewicz, R.T. Smolenski, E. M. Slominska

DOXORUBICIN EFFECTS ON LEUKEMIA AND BREAST CANCER CELLS IN CULTURE ON THE TK1 PROTEIN LEVELS USING AROCELL TK 210 ELISA: A TOOL FOR DRUG DEVELOPMENT. J. Kiran Kumar, L. Wang, S. Eriksson


Payment of registration fee (until 30th July 2017)

Registration fee (until 30th July 2017)

** Copy of a valid student card required or another type of verification.

Payment of registration fee (after 30th July 2017)

Registration fee (after 30th July 2017)

** Copy of a valid student card required or another type of verification.